Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. I. Taxonomy, production, isolation and preliminary characterization.

The Journal of antibiotics ·Vol. 39 ·No. 6 ·1986-06-00 ·Pages 737-44

Umezawa H, Aoyagi T, Nishikiori T, Okuyama A, Yamagishi Y, Hamada M, Takeuchi T

Abstract

Plipastatins have been isolated as part of a program designed to find inhibitors of porcine pancreatic phospholipase A2. They were purified from fermentation broth of Bacillus cereus BMG302-fF67 and finally separated into four fractions by reverse phase HPLC. The respective fractions were designated as plipastatins A1, A2, B1 and B2. Plipastatins also inhibited phospholipases C and D.

MeSH Terms

Animals Anti-Bacterial Agents/isolation & purification,pharmacology Bacillus cereus/classification,metabolism Chemical Phenomena Chemistry Fatty Acids/isolation & purification,pharmacology Mice Oligopeptides/isolation & purification,pharmacology Peptides, Cyclic Phospholipases/antagonists & inhibitors Phospholipases A/antagonists & inhibitors Phospholipases A2

Chemicals

Anti-Bacterial Agents Fatty Acids Oligopeptides Peptides, Cyclic plipastatin Phospholipases Phospholipases A Phospholipases A2

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Umezawa H

Aoyagi T

Nishikiori T

Okuyama A

Yamagishi Y

Hamada M

Takeuchi T

Article Info

Journal

The Journal of antibiotics

Abbr.

J Antibiot (Tokyo)

ISSN

0021-8820

DOI

10.7164/antibiotics.39.737

Published

1986-06-00

Pages

737-44

Language

English

Region

Japan

NLM ID

0151115

Subset

External Links

PubMed source DOI: 10.7164/antibiotics.39.737 View journal details

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Plipastatins: new inhibitors of phospholipase A2, produced by Bacillus cereus BMG302-fF67. I. Taxonomy, production, isolation and preliminary characterization.

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