Home LiteratureArticle Details

PMID: 3082980 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 136 ·No. 8 ·1986-04-15 ·Pages 3092-7

Sugiyama H, Maeda T, Akira S, Kishimoto S

Abstract

An Abelson virus-transformed murine pre-B cell line class-switched from mu to gamma 3 or gamma 2b at the pre-B stage during culture. A class-switch was mediated by the deletion mechanism of the intervening CH genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to gamma 2b production.

MeSH Terms

Animals B-Lymphocytes/metabolism Chromosome Deletion Clone Cells/metabolism Immunoglobulin Allotypes/biosynthesis,classification,genetics Immunoglobulin Constant Regions/genetics Immunoglobulin Heavy Chains/biosynthesis,genetics Immunoglobulin J-Chains/genetics Immunoglobulin Variable Region/genetics Immunoglobulin gamma-Chains/biosynthesis,genetics Immunoglobulin mu-Chains/biosynthesis,genetics Mice Mice, Inbred BALB C Nucleic Acid Hybridization Stem Cells/metabolism

Chemicals

Immunoglobulin Allotypes Immunoglobulin Constant Regions Immunoglobulin Heavy Chains Immunoglobulin J-Chains Immunoglobulin Variable Region Immunoglobulin gamma-Chains Immunoglobulin mu-Chains

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sugiyama H

Maeda T

Akira S

Kishimoto S

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1986-04-15

Pages

3092-7

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

Analysis Services

Class-switching from mu to gamma 3 or gamma 2b production at pre-B cell stage.

Contact

WeChat Official Account