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PMID: 3082591 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

The bioavailability of ethinyloestradiol and levonorgestrel in patients with an ileostomy.

Contraception ·Vol. 33 ·No. 1 ·1986-01-00 ·Pages 51-9

Grimmer SF, Back DJ, Orme ML, Cowie A, Gilmore I, Tjia J

Abstract

The bioavailability of ethinyloestradiol and levonorgestrel has been studied in 5 young women with an ileostomy following surgery for ulcerative colitis and compared to that in 5 control subjects. Single i.v. and oral doses of both drugs were administered and the bioavailability calculated from the ratio of the two areas under the plasma concentration versus time curve for the two drugs. The mean bioavailability of ethinyloestradiol in the patients with an ileostomy was 55.4 +/- 10.9% (+/- S.D.) compared to a control value of 45.0 +/- 6.1% (p greater than or equal to 0.1). The mean bioavailability of levonorgestrel in the ileostomy patients was 85.2 +/- 13.1% compared to 104.6 +/- 22.3% in the controls (p greater than or equal to 0.1). Women who have an ileostomy following lower bowel surgery can rely on their oral contraceptive preparations being absorbed in the normal way.

Keywords
Biology Contraception Contraceptive Agents Estrogen--administraction and dosage Contraceptive Agents Estrogen--analysis Contraceptive Agents Estrogen--pharmacodynamics Contraceptive Agents Female--administraction and dosage Contraceptive Agents Female--analysis Contraceptive Agents Female--pharmacodynamics Contraceptive Agents Progestin--administraction and dosage Contraceptive Agents Progestin--analysis Contraceptive Agents Progestin--pharmacodynamics Contraceptive Agents--administraction and dosage Contraceptive Agents--analysis Contraceptive Agents--pharmacodynamics Diseases Endocrine System Ethinyl Estradiol--administraction and dosage Ethinyl Estradiol--analysis Ethinyl Estradiol--pharmacodynamics Family Planning Gastrointestinal Effects Hormones Levonorgestrel--administraction and dosage Levonorgestrel--analysis Levonorgestrel--pharmacodynamics Physiology Reproductive Control Agents Surgery Treatment
MeSH Terms
Adult Biological Availability Contraceptives, Oral, Combined Ethinyl Estradiol/blood,metabolism Female Humans Ileostomy Kinetics Levonorgestrel Norgestrel/blood,metabolism Time Factors
Chemicals
Contraceptives, Oral, Combined Norgestrel Ethinyl Estradiol Levonorgestrel
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Grimmer S F
Back D J
Orme M L
Cowie A
Gilmore I
Tjia J
Article Info
Journal
Contraception
Abbr.
Contraception
ISSN
0010-7824
DOI
10.1016/0010-7824(86)90032-6
Published
1986-01-00
Pages
51-9
Language
English
Region
United States
NLM ID
0234361
Subset
IM
External Links
PubMed source DOI: 10.1016/0010-7824(86)90032-6 View journal details
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