Cytotoxic T cells recognize male antigen and H-2 as distinct entities.
XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice depleted of alloreactive T cells, however, cannot be sensitized to lyse allogeneic XY targets. The results imply that T cells recognize the Y-antigen and H-2 as distinct entities, and that in chimeras, they acquire the potential to react against allogeneic XY cells.
9 references, click to expand
-
A hormone-like action of H-Y antigen and gonadal development of XY/XX mosaic males and hermaphrodites.Hum Genet. 1976 Dec 29;35(1):21-5 PMID: 63444
-
Responsiveness to HY antigen Ir gene complementation and target cell specificity.Immunol Rev. 1977;35:59-75 PMID: 70400
-
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med. 1978 Mar 1;147(3):882-96 PMID: 305459
-
H-2 gene complementation in cytotoxic T cell responses of female against male cells.Eur J Immunol. 1977 Jul;7(7):443-7 PMID: 302210
-
The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.J Exp Med. 1977 Aug 1;146(2):361-7 PMID: 301550
-
Effect of recent antigen priming on adoptive immune responses. III. Antigen-induced selective recruitment of subsets of recirculating lymphocytes reactive to H-2 determinants.J Exp Med. 1976 Mar 1;143(3):585-600 PMID: 55460
-
Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras.J Exp Med. 1975 Feb 1;141(2):322-34 PMID: 46268
-
Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.J Exp Med. 1976 Apr 1;143(4):999-1004 PMID: 1082923
-
Hormone-like role of H-Y antigen in bovine freemartin gonad.Nature. 1976 Jun 17;261(5561):597-9 PMID: 934301
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
