Home LiteratureArticle Details
PMID: 3060369 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A retrospective study of Creutzfeldt-Jakob disease in Italy (1972-1986).

European journal of epidemiology ·Vol. 4 ·No. 4 ·1988-12-00 ·Pages 482-7

Masullo C, Pocchiari M, Neri G, Casaccia P, Iavarone A, Ladogana A, Macchi G

Abstract

In a retrospective study of Creutzfeldt-Jakob disease (CJD) in Italy from 1972 to 1986, we found 79 cases which fulfilled the diagnostic criteria for CJD. The annual mortality rate was 0.09 cases per million inhabitants. In this series the female to male ratio was 2.59, a value significantly higher than that found in Italian population (1.05). The mean age at death was 62.1 +/- 9.4 years and the mean duration of the disease was 5.3 +/- 3.0 months. No familial cases of CJD were found in our series. Mental deterioration was present in all of our cases, myoclonus in 85% and the other clinical signs were present at a lower rate. Periodic EEG activity was found in 92% of the cases. Two patients had had neurological or ophthalmic surgery and 17% of our cases had undergone general surgery within 5 years prior to the clinical onset of CJD.

MeSH Terms
Adult Age Factors Aged Aged, 80 and over Creutzfeldt-Jakob Syndrome/diagnosis,epidemiology,mortality Dementia/epidemiology Female Humans Italy Male Middle Aged Occupations Retrospective Studies Risk Factors Sex Factors
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Masullo C
Istituto di Neurologia, Università Cattolica S. Cuore, Rome, Italy.
Pocchiari M
Neri G
Casaccia P
Iavarone A
Ladogana A
Macchi G
References (23)
23 references, click to expand
  1. Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery.
    Lancet. 1977 Feb 26;1(8009):478-9 PMID: 65575
  2. Creutzfeldt-Jakob disease in France: III. Epidemiological study of 170 patients dying during the decade 1968--1977.
    Ann Neurol. 1979 Nov;6(5):438-46 PMID: 391142
  3. A case control study of Creutzfeldt-Jakob disease: association with physical injuries.
    Ann Neurol. 1982 Apr;11(4):377-81 PMID: 7049055
  4. High incidence of Creutzfeldt-Jakob disease in North African immigrants to France.
    Neurology. 1985 Jun;35(6):894-5 PMID: 3889706
  5. Creutzfeldt-Jakob disease.
    J Neuropathol Exp Neurol. 1985 Jan;44(1):1-17 PMID: 3880808
  6. Creutzfeld-Jakob disease: clinical, EEG and neuropathological findings in a cluster of eleven patients.
    Ital J Neurol Sci. 1983 Apr;4(1):47-59 PMID: 6345459
  7. Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering.
    Ann Neurol. 1979 Feb;5(2):177-88 PMID: 371520
  8. Creutzfeldt-Jakob disease in Japan.
    Neurology. 1983 Nov;33(11):1503-6 PMID: 6355897
  9. [Four cases of Creutzfeldt-Jakob's disease (author's transl)].
    Riv Patol Nerv Ment. 1978 Nov-Dec;99(6):349-65 PMID: 388601
  10. Descriptive epidemiology of Creutzfeldt-Jakob disease in Chile.
    Arch Neurol. 1980 Jan;37(1):11-4 PMID: 6985793
  11. Panencephalopathic type of Creutzfeldt-Jakob disease: primary involvement of the cerebral white matter.
    J Neurol Neurosurg Psychiatry. 1981 Feb;44(2):103-15 PMID: 7012278
  12. Creutzfeld-Jakob disease in the province of Siena: two cases transmitted to monkeys.
    Ital J Neurol Sci. 1983 Apr;4(1):61-4 PMID: 6345460
  13. A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-79. I: Clinical features.
    J Neurol Neurosurg Psychiatry. 1984 Feb;47(2):134-40 PMID: 6368752
  14. Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy.
    N Engl J Med. 1985 Sep 19;313(12):728-31 PMID: 3929089
  15. Unconventional viruses and the origin and disappearance of kuru.
    Science. 1977 Sep 2;197(4307):943-60 PMID: 142303
  16. The epidemiology of Creutzfeldt-Jakob disease: conclusion of a 15-year investigation in France and review of the world literature.
    Neurology. 1987 Jun;37(6):895-904 PMID: 3295589
  17. Experimental subacute spongiform virus encephalopathies in primates and other laboratory animals.
    Science. 1973 Oct 5;182(4107):67-8 PMID: 4199733
  18. Creutzfeldt-Jakob disease: clinical analysis of a consecutive series of 230 neuropathologically verified cases.
    Ann Neurol. 1986 Nov;20(5):597-602 PMID: 3539001
  19. [Histopathologic aspects of Creutzfeld-Jacob disease].
    Riv Patol Nerv Ment. 1970 Apr;91(2):69-84 PMID: 4946968
  20. Creutzfeldt-Jakob disease in the city and district of Genoa: estimated mortality rate in the six year period 1974-1979.
    Ital J Neurol Sci. 1981 May;2(2):189-92 PMID: 7037679
  21. Letter: Possible person-to-person transmission of Creutzfeldt-Jakob disease.
    N Engl J Med. 1974 Mar 21;290(12):692-3 PMID: 4591849
  22. On the white matter lesions of the Creutzfeldt-Jakob disease. Can a new subentity be recognized in man?
    J Neurol Sci. 1984 Feb;63(2):197-206 PMID: 6368755
  23. A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970-1979. II: Epidemiology.
    J Neurol Neurosurg Psychiatry. 1986 Jul;49(7):749-55 PMID: 3528394
Article Info
Journal
European journal of epidemiology
Abbr.
Eur J Epidemiol
ISSN
0393-2990
DOI
10.1007/BF00146403
Published
1988-12-00
Pages
482-7
Language
English
Region
Netherlands
NLM ID
8508062
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00146403 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2