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PMID: 3053667 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions.

Journal of bacteriology ·Vol. 170 ·No. 11 ·1988-11-00 ·Pages 5405-7

Cabrera M, Nghiem Y, Miller JH

Abstract

We used strains carrying specific lacZ alleles to identify a new mutator locus in Escherichia coli which generates only G.C----T.A transversions among base substitutions. The locus, mutM, mapped near the cysE locus, which is at 81 min on the genetic map.

MeSH Terms

Base Composition Escherichia coli/genetics Genes, Bacterial Mutation Restriction Mapping

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Cabrera M

Department of Biology, University of California, Los Angeles 90024.

Nghiem Y

Miller J H

References (13)

13 references, click to expand

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.
Proc Natl Acad Sci U S A. 1987 Sep;84(17):6220-4 PMID: 3306672
Repair of defined single base-pair mismatches in Escherichia coli.
Proc Natl Acad Sci U S A. 1985 Jan;82(2):503-5 PMID: 16593539
Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli.
Cell. 1984 Oct;38(3):879-87 PMID: 6386179
Analysis of spontaneous base substitutions generated in mismatch-repair-deficient strains of Escherichia coli.
J Bacteriol. 1986 Oct;168(1):412-6 PMID: 3531178
Mutation spectrum in Escherichia coli DNA mismatch repair deficient (mutH) strain.
Nucleic Acids Res. 1987 Oct 26;15(20):8205-15 PMID: 3313278
Repair of a mismatch is influenced by the base composition of the surrounding nucleotide sequence.
Genetics. 1987 Apr;115(4):605-10 PMID: 2953650
Repair of DNA base-pair mismatches in extracts of Escherichia coli.
Cold Spring Harb Symp Quant Biol. 1984;49:589-96 PMID: 6397313
Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli.
J Mol Biol. 1977 Dec 15;117(3):577-606 PMID: 416218
The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2709-13 PMID: 3128795
Mutations in a new gene, secB, cause defective protein localization in Escherichia coli.
J Bacteriol. 1983 Apr;154(1):253-60 PMID: 6403503
Repair of single base-pair transversion mismatches of Escherichia coli in vitro: correction of certain A/G mismatches is independent of dam methylation and host mutHLS gene functions.
Genetics. 1988 Apr;118(4):593-600 PMID: 3284785
The specificity of base-pair substitution induced by the mutL and mutS mutators in E. coli.
Mutat Res. 1985 Mar;142(3):93-7 PMID: 3883143
Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment.
Cell. 1984 Jun;37(2):675-82 PMID: 6373019

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.170.11.5405-5407.1988

Published

1988-11-00

Pages

5405-7

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC211625

Subset

Grants

NIGMS NIH HHS · GM32184 · United States

External Links

PubMed source DOI: 10.1128/jb.170.11.5405-5407.1988 PMC Full Text View journal details

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