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PMID: 305114 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Irreversible inhibition of sodium entry sites in frog skin by a photosensitive amiloride analog.

Science (New York, N.Y.) ·Vol. 199 ·No. 4334 ·1978-03-17 ·Pages 1205-6

Benos DJ, Mandel LJ

Abstract

A photosensitive binding reaction is described in which an analog of amiloride is bound to sites that control sodium entry into frog skin. This reaction results in irreversible inhibition of net sodium transport.

MeSH Terms
Amiloride/analogs & derivatives,pharmacology,radiation effects Animals Anura Biological Transport/drug effects Depression, Chemical Pyrazines/pharmacology Rana catesbeiana Skin/drug effects,metabolism Sodium/metabolism Ultraviolet Rays
Chemicals
Pyrazines Amiloride Sodium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Benos D J
Mandel L J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.305114
Published
1978-03-17
Pages
1205-6
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.305114 View journal details
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