Home LiteratureArticle Details
PMID: 30443490 Published · ppublish English Journal Article Comment

Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy.

Translational cancer research ·Vol. 7 ·No. Suppl 5 ·2018-06-00 ·Pages S608-S610

Liu K, Lu C

Abstract

暂无摘要

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Liu Kebin
Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA. | Cancer Immunology, Inflammation and Tolerance Program, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.
Lu Chunwan
Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA. | Cancer Immunology, Inflammation and Tolerance Program, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.
Conflict of Interest

Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.

References (20)
20 references, click to expand
  1. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.
    Science. 2015 Nov 27;350(6264):1079-84 PMID: 26541610
  2. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.
    Sci Transl Med. 2016 Mar 2;8(328):328rv4 PMID: 26936508
  3. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.
    Science. 2017 Mar 31;355(6332):1428-1433 PMID: 28280247
  4. Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells.
    BMC Cancer. 2018 Feb 6;18(1):149 PMID: 29409480
  5. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
    Science. 2018 Jan 5;359(6371):91-97 PMID: 29097494
  6. Proton pump inhibitors alter the composition of the gut microbiota.
    Gut. 2016 May;65(5):749-56 PMID: 26719299
  7. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway.
    N Engl J Med. 2016 Nov 3;375(18):1767-1778 PMID: 27806234
  8. Structure, function and diversity of the healthy human microbiome.
    Nature. 2012 Jun 13;486(7402):207-14 PMID: 22699609
  9. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.
    Science. 2018 Jan 5;359(6371):97-103 PMID: 29097493
  10. Microbes and Cancer.
    Annu Rev Immunol. 2017 Apr 26;35:199-228 PMID: 28142322
  11. Hallmarks of cancer: the next generation.
    Cell. 2011 Mar 4;144(5):646-74 PMID: 21376230
  12. The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.
    Cancer Cell. 2018 Apr 9;33(4):570-580 PMID: 29634945
  13. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
    Science. 2015 Nov 27;350(6264):1084-9 PMID: 26541606
  14. The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.
    J Natl Cancer Inst. 2017 Jan 28;109(6): PMID: 28131992
  15. Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development.
    Sci Rep. 2017 Nov 3;7(1):14472 PMID: 29101397
  16. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
    Science. 1994 Jul 22;265(5171):528-30 PMID: 7518614
  17. PD-1 and its ligands in tolerance and immunity.
    Annu Rev Immunol. 2008;26:677-704 PMID: 18173375
  18. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
    Cancer Res. 2005 Feb 1;65(3):1089-96 PMID: 15705911
  19. Dysbiosis and the immune system.
    Nat Rev Immunol. 2017 Apr;17(4):219-232 PMID: 28260787
  20. A framework for human microbiome research.
    Nature. 2012 Jun 13;486(7402):215-21 PMID: 22699610
Article Info
Journal
Translational cancer research
Abbr.
Transl Cancer Res
ISSN
2218-676X
Published
2018-06-00
Pages
S608-S610
Language
English
Region
China
NLM ID
101585958
PMCID
PMC6233902
Grants
NCI NIH HHS · R01 CA133085 · United States
NCI NIH HHS · R01 CA182518 · United States
NCI NIH HHS · R43 CA221414 · United States
Corrections
CommentOn
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com