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PMID: 303775 Published · ppublish English Journal Article

Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 11 ·1977-11-00 ·Pages 5126-30

Urbain J, Wikler M, Franssen JD, Collignon C

Abstract

Anticarbohydrate antibodies (Ab1) were isolated from a rabbit hyperimmunized with Micrococcus lysodeikticus and injected into allotype-matched rabbits in order to obtain specific anti-iodiotypic antibodies (Ab2). Ab2 was isolated by means of a Sepharose column coupled to the anticarbohydrate antibodies and was injected into two allotype-matched rabbits. These latter rabbits produced specific anti-anti-idiotypic antibodies (Ab3) probably sharing idiotypic specificities with Ab1. However, these Ab3 did not react with the antigenic carbohydrate moiety of bacteria. The two rabbits that had produced Ab3 were then immunized with M. lysodeikticus and synthesized anticarbohydrate antibodies (Ab1') bearing idiotypic specificities similar to those of Ab1. The immune repertoire which is effectively expressed in one individual depends not only on the antigenic stimulation but also on the previous idiotypic history of the individual. These data support the concept that the immune system is a functional idiotypic network.

MeSH Terms
Animals Antibodies, Anti-Idiotypic/biosynthesis Antibodies, Bacterial/biosynthesis Antibody Formation Antibody Specificity Antigen-Antibody Reactions/drug effects Carbohydrates/immunology Cross Reactions Micrococcus/immunology Rabbits/immunology Radioimmunoassay
Chemicals
Antibodies, Anti-Idiotypic Antibodies, Bacterial Carbohydrates
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Urbain J
Wikler M
Franssen J D
Collignon C
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.11.5126
Published
1977-11-00
Pages
5126-30
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432113
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.11.5126 PMC Full Text View journal details
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