Identification of a family of muscarinic acetylcholine receptor genes.

Science (New York, N.Y.) ·Vol. 237 ·No. 4814 ·1987-07-31 ·Pages 527-32

Bonner TI, Buckley NJ, Young AC, Brann MR

Abstract

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Brain/metabolism Cloning, Molecular Codon DNA DNA Restriction Enzymes Genes Genetic Code Humans Models, Molecular Nucleic Acid Hybridization Rats Receptors, Muscarinic/classification,genetics Swine Transfection

Chemicals

Codon Receptors, Muscarinic DNA DNA Restriction Enzymes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bonner T I

Buckley N J

Young A C

Brann M R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.3037705

Published

1987-07-31

Pages

527-32

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

M16404, M16405, M16406, M16407, M16408, M16409

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1126/science.3037705 View journal details

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Identification of a family of muscarinic acetylcholine receptor genes.

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