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PMID: 3033516 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Highly potent and selective ligands for histamine H3-receptors.

Nature ·Vol. 327 ·No. 6118 ·1987-00-00 ·Pages 117-23

Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, Schunack W, Schwartz JC

Abstract

New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provide new tools for affecting physiological and possibly pathological conditions in which histamine is involved.

MeSH Terms

Animals Binding, Competitive Brain Feedback Histamine/physiology Male Methylhistamines/pharmacology Molecular Conformation Piperidines/pharmacology Rats Rats, Inbred Strains Receptors, Histamine/analysis,drug effects,physiology Receptors, Histamine H3 Tissue Distribution

Chemicals

Methylhistamines Piperidines Receptors, Histamine Receptors, Histamine H3 Histamine thioperamide N-methylhistamine

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Arrang J M

Garbarg M

Lancelot J C

Lecomte J M

Pollard H

Robba M

Schunack W

Schwartz J C

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/327117a0

Published

1987-00-00

Pages

117-23

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/327117a0 View journal details

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Highly potent and selective ligands for histamine H3-receptors.

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