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PMID: 3030805 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.

FEBS letters ·Vol. 213 ·No. 1 ·1987-03-09 ·Pages 15-7

Halliwell B, Wasil M, Grootveld M

Abstract

Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.

MeSH Terms

Antioxidants/therapeutic use Arthritis, Rheumatoid/drug therapy Ascorbic Acid/therapeutic use Chromatography, High Pressure Liquid Hydrogen-Ion Concentration Hydroxides Hydroxyl Radical Hypochlorous Acid/metabolism Oxidation-Reduction Pancreatic Elastase/antagonists & inhibitors Peroxidase/metabolism alpha 1-Antitrypsin/antagonists & inhibitors

Chemicals

Antioxidants Hydroxides alpha 1-Antitrypsin Hydroxyl Radical Hypochlorous Acid Peroxidase Pancreatic Elastase Ascorbic Acid

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Halliwell B

Wasil M

Grootveld M

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(87)81456-4

Published

1987-03-09

Pages

15-7

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(87)81456-4 View journal details

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Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.

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