Abstract
An Epstein-Barr viral gene (ZEBRA) is identified that, in human lymphoblastoid cells, activates a switch causing the virus to shift from the latent to the replicative phase of its life cycle. We have shown that a 2.7-kilobase-pair rearranged Epstein-Barr virus DNA fragment of this gene (BamHI fragment WZhet) induced transient expression of viral replicative antigens and polypeptides when it was transfected into a somatic cell hybrid, which was derived from the fusion of an epithelial line cell with a Burkitt lymphoma cell. We now show that this rearranged WZhet fragment, when introduced stably into lymphoblastoid cells, will activate expression of the complete viral replicative cycle in 1-10% of the lymphoblastoid cells, leading to production of biologically active virions that can immortalize primary lymphocytes. The transfected plasmid appears to be regulated in a manner analogous to the complete Epstein-Barr virus genome.
MeSH Terms
Antigens, Viral/analysis
Cell Line
Cell Transformation, Viral
DNA Replication
Genes, Viral
Herpesvirus 4, Human/genetics
Humans
Lymphocytes
Plasmids
Transfection
Virus Replication
Chemicals
Antigens, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Grogan E
Jenson H
Countryman J
Heston L
Gradoville L
Miller G
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