Home LiteratureArticle Details
PMID: 301506 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunology of the infant rat experimental model of Haemophilus influenzae type b meningitis.

Infection and immunity ·Vol. 16 ·No. 1 ·1977-04-00 ·Pages 218-25

Myerowitz RL, Norden CW

Abstract

The age-related acquisition of serum anticapsular and bactericidal antibodies to Haemophilus influenzae type b observed in rats was similar to that of humans. The antigenic source for this "natural" immunity was not identified since neither pharyngeal infection with H. influenzae b nor enteric colonization by cross-reacting bacteria was detected. Infant rats surviving H. influenzae b bacteremia failed to respond immunologically to the capsular polysaccharide. However, surviving rats demonstrated no impairment of immune responsiveness to this antigen after subsequent immunization with live bacteria in adulthood. In passive protection experiments, antibodies directed against the type b capsular polysaccharide represented the major protective specificity. However, a small protective effect of antibodies to noncapsular antigens also appeared to have been demonstrated.

MeSH Terms
Aging Animals Animals, Newborn Antibody Formation Antigens, Bacterial Disease Models, Animal Female Haemophilus influenzae/immunology Immune Tolerance Immunity, Maternally-Acquired Meningitis, Haemophilus/immunology Rabbits Rats Sepsis/immunology
Chemicals
Antigens, Bacterial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Myerowitz R L
Norden C W
References (24)
24 references, click to expand
  1. BACTERIAL MENINGITIS--A REVIEW OF SELECTED ASPECTS. 1. GENERAL CLINICAL FEATURES, SPECIAL PROBLEMS AND UNUSUAL MENINGEAL REACTIONS MIMICKING BACTERIAL MENINGITIS.
    N Engl J Med. 1965 Apr 8;272:725-31 CONTD PMID: 14261465
  2. Studies on the mechanism of the immunological paralysis induced in mice by pneumococcal polysaccharides.
    J Immunol. 1955 Jan;74(1):17-26 PMID: 13233513
  3. Hemophilus influenzae, type b, antibody frequencies determined with bactericidal and radioimmunoassay tests.
    J Clin Microbiol. 1976 AUG;2(2):136-8 PMID: 1085776
  4. Experimental endogenous endophthalmitis caused by Haemophilus influenzae type b.
    Infect Immun. 1976 Oct;14(4):1043-51 PMID: 1086831
  5. Enteric bacteria cross-reactive with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and 3.
    Infect Immun. 1972 Nov;6(5):651-6 PMID: 4118016
  6. Quantitative measurement of "natural" and immunization-induced Haemophilus influenzae type b capsular polysaccharide antibodies.
    Pediatr Res. 1973 Mar;7(3):103-10 PMID: 4120458
  7. Bacterial antigens cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b.
    Lancet. 1971 May 29;1(7709):1095-6 PMID: 4102623
  8. Polysaccharides of the genus Bacillus cross-reactive with the capsular polysaccharides of Diplococcus pneumoniae type 3, Haemophilus influenzae type b, and Neisseria meningitidis group A.
    Infect Immun. 1973 Dec;8(6):896-900 PMID: 4150383
  9. Immunologic responses to Hemophilus influenzae meningitis.
    J Pediatr. 1972 Feb;80(2):209-14 PMID: 4621513
  10. Haemophilus influenzae meningitis in infant rats after intranasal inoculation.
    J Infect Dis. 1974 Feb;129(2):154-62 PMID: 4590004
  11. Haemophilus influenzae type b: disease and immunity in humans.
    Ann Intern Med. 1973 Feb;78(2):259-69 PMID: 4567179
  12. Production of Haemophilus influenzae b meningitis in infant rats by intraperitoneal inoculation.
    Infect Immun. 1973 Aug;8(2):278-90 PMID: 4542033
  13. Responses of children immunized with the capsular polysaccharide of Hemophilus influenzae, type b.
    Pediatrics. 1973 Nov;52(5):637-44 PMID: 4542777
  14. Countercurrent immunoelectrophoresis for the diagnosis of pneumococcal pneumonia in children.
    J Pediatr. 1976 Jan;88(1):72-4 PMID: 1482
  15. Immunologic response in patients with epiglottitis caused by Haemophilus influenzae type b.
    J Infect Dis. 1973 Dec;128(6):777-80 PMID: 4543603
  16. Prevalence of bactericidal antibodies to Haemophilus influenzae, type b.
    J Infect Dis. 1974 Nov;130(5):489-94 PMID: 4547367
  17. Variable susceptibility of Hemophilus influenzae, type B strains to serum bactericidal activity.
    Proc Soc Exp Biol Med. 1972 Jan;139(1):59-61 PMID: 4536639
  18. Immunization of humans with polyribophosphate, the capsular antigen of Hemophilus influenzae, type b.
    J Clin Invest. 1972 Jan;51(1):39-44 PMID: 4536615
  19. Human serum activities against Hemophilus influenzae, type b.
    J Clin Invest. 1972 Jan;51(1):31-8 PMID: 4536614
  20. Immunity to disease caused by Hemophilus influenzae type b. II. Specificity and some biologic characteristics of "natural," infection-acquired, and immunization-induced antibodies to the capsular polysaccharide of Hemophilus influenzae type b.
    J Immunol. 1971 Oct;107(4):1081-9 PMID: 5315273
  21. Reassessment of the role of bactericidal antibody in Hemophilus influenzae infection.
    Am J Med Sci. 1971 Dec;262(6):338-46 PMID: 5317007
  22. Immunity to Haemophilus influenzae type B: the role of the capsular antibody.
    J Med Microbiol. 1971 Feb;4(1):85-8 PMID: 5313419
  23. Use of antiserum agar for detection of Haemophilus influenzae type b in the pharynx.
    Pediatr Res. 1975 May;9(5):513-6 PMID: 1094393
  24. Effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of Haemophilus influenzae Type b.
    J Infect Dis. 1975 Jul;132(1):69-74 PMID: 1080178
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.16.1.218-225.1977
Published
1977-04-00
Pages
218-25
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421511
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.16.1.218-225.1977 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2