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PMID: 3012422 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Collagenase digestion alters the organization and turnover of junctional acetylcholine receptors.

Neuroscience letters ·Vol. 66 ·No. 1 ·1986-05-06 ·Pages 113-9

Bloch RJ, Steinbach JH, Merlie JP, Heinemann S

Abstract

Acetylcholine receptors at the vertebrate neuromuscular junction are highly organized and metabolically very stable. We report here that digestion of adult rat skeletal muscle with collagenase disorganizes junctional receptors and increases their turnover rate.

MeSH Terms

Animals Diaphragm/innervation Histological Techniques Microbial Collagenase/pharmacology Motor Endplate/ultrastructure Neuromuscular Junction/metabolism Osmolar Concentration Rats Receptors, Cholinergic/drug effects,metabolism

Chemicals

Receptors, Cholinergic Microbial Collagenase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bloch R J

Steinbach J H

Merlie J P

Heinemann S

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(86)90175-8

Published

1986-05-06

Pages

113-9

Language

English

Region

Ireland

NLM ID

7600130

Subset

Grants

NINDS NIH HHS · NS 00679 · United States

External Links

PubMed source DOI: 10.1016/0304-3940(86)90175-8 View journal details

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Collagenase digestion alters the organization and turnover of junctional acetylcholine receptors.

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