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PMID: 3010051 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function.

Molecular & general genetics : MGG ·Vol. 202 ·No. 2 ·1986-02-00 ·Pages 291-3

Hayles J, Beach D, Durkacz B, Nurse P

Abstract

A DNA fragment called suc1 has been found to rescue cells mutated in the cell cycle control gene cdc2 of the fission yeast Schizosaccharomyces pombe. The suppressing activity of suc1 is observed when it is present on a multicopy number plasmid. The gene does not hybridize to cdc2 and maps elsewhere in the genome. Its effect is cdc2 allele specific suggesting that it interacts directly with the cdc2 gene function.

MeSH Terms
Base Sequence Cell Cycle DNA Restriction Enzymes Genes, Fungal Mutation Saccharomycetales/genetics Schizosaccharomyces/cytology,genetics Suppression, Genetic
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hayles J
Beach D
Durkacz B
Nurse P
References (6)
6 references, click to expand
  1. Functionally homologous cell cycle control genes in budding and fission yeast.
    Nature. 1982 Dec 23;300(5894):706-9 PMID: 6757758
  2. Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases.
    Gene. 1984 Nov;31(1-3):129-34 PMID: 6526270
  3. Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes.
    Nature. 1984 Jan 12-18;307(5947):183-5 PMID: 6361575
  4. Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast.
    Nature. 1981 Aug 6;292(5823):558-60 PMID: 7254352
  5. Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe.
    Genetics. 1980 Nov;96(3):627-37 PMID: 7262540
  6. Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation.
    Mol Gen Genet. 1982;187(2):326-9 PMID: 6294466
Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
Published
1986-02-00
Pages
291-3
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
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