Complex-specific immunoglobulin M antibody patterns in humans infected with alphaviruses.

Journal of clinical microbiology ·Vol. 23 ·No. 1 ·1986-01-00 ·Pages 155-9

Calisher CH, el-Kafrawi AO, Al-Deen Mahmud MI, Travassos da Rosa AP, Bartz CR, Brummer-Korvenkontio M, Haksohusodo S, Suharyono W

Abstract

Sera from humans with serologically confirmed eastern equine encephalitis, western equine encephalitis, Pogosta (Ockelbo), Mayaro, Ross River, and chikungunya virus infections were tested by immunoglobulin M (IgM) antibody capture enzyme immunoassay. Diagnostically useful IgM antibody titers were detected, and selected sera with high IgM antibody titers were tested for IgM antibody with nine heterologous alphaviruses. The results provide evidence for the complex specificity of IgM antibody and indicate the usefulness of this test in both individual cases and epidemic situations.

MeSH Terms

Alphavirus/immunology Antibodies, Viral/analysis,immunology Antibody Specificity Antigens, Viral/immunology Chikungunya virus/immunology Cross Reactions Encephalitis Virus, Eastern Equine/immunology Encephalitis Virus, Western Equine/immunology Encephalomyelitis, Equine/diagnosis,immunology Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin M/analysis,immunology Ross River virus/immunology Semliki forest virus/immunology Sindbis Virus/immunology Togaviridae Infections/diagnosis,immunology

Chemicals

Antibodies, Viral Antigens, Viral Immunoglobulin M

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Calisher C H

el-Kafrawi A O

Al-Deen Mahmud M I

Travassos da Rosa A P

Bartz C R

Brummer-Korvenkontio M

Haksohusodo S

Suharyono W

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12 references, click to expand

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Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/jcm.23.1.155-159.1986

Published

1986-01-00

Pages

155-9

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC268591

Subset

External Links

PubMed source DOI: 10.1128/jcm.23.1.155-159.1986 PMC Full Text View journal details

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Complex-specific immunoglobulin M antibody patterns in humans infected with alphaviruses.

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