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PMID: 3004938 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Activation of c-erbB in avian leukosis virus-induced erythroblastosis leads to the expression of a truncated EGF receptor kinase.

The EMBO journal ·Vol. 4 ·No. 12 ·1985-12-01 ·Pages 3179-82

Lax I, Kris R, Sasson I, Ullrich A, Hayman MJ, Beug H, Schlessinger J

Abstract

Chicken erythroblastosis caused by avian leukosis virus (ALV) is thought to be mediated by activation of the c-erbB/EGF receptor oncogene by a promoter-insertion mechanism. Here we study the proteins expressed by two ALV-induced leukemias and compare them with the avian EGF receptor and with the oncogene product of avian erythroblastosis virus (v-erbB) which was shown to be a truncated EGF receptor. It appears that the two leukemias express truncated EGF receptors of slightly different sizes with intrinsic tyrosine kinase activity. Hence, acute and chronic retroviruses utilize a common pathway for transformation. Moreover, the proteins expressed in the leukemias are similar to the avian EGF receptor with respect to their phosphopeptide maps, suggesting that they do not carry the C-terminal deletion characteristic of v-erbB.

MeSH Terms
Alpharetrovirus/genetics Amino Acids/analysis Animals Avian Leukosis/microbiology Avian Leukosis Virus/genetics Cell Line Cell Transformation, Neoplastic Chickens ErbB Receptors Genes Genes, Viral Oncogenes Phosphorylation Protein-Tyrosine Kinases/genetics,metabolism
Chemicals
Amino Acids ErbB Receptors Protein-Tyrosine Kinases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Lax I
Kris R
Sasson I
Ullrich A
Hayman M J
Beug H
Schlessinger J
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17 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1985-12-01
Pages
3179-82
Language
English
Region
England
NLM ID
8208664
PMCID
PMC554639
Subset
IM
Grants
NCI NIH HHS · CA 25820 · United States
External Links
PubMed source PMC Full Text View journal details
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