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PMID: 3004203 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.

American journal of human genetics ·Vol. 38 ·No. 1 ·1986-01-00 ·Pages 59-66

Dryja TP, Rapaport JM, Epstein J, Goorin AM, Weichselbaum R, Koufos A, Cavenee WK

Abstract

We provide evidence that some human osteosarcomas arise subsequent to the development of homozygosity at loci on the long arm of chromosome 13. The resulting chromosome 13q homozygosity allows the phenotypic expression of any recessive allele on that chromosome. Clinical evidence suggests that it is the retinoblastoma locus within 13q14 that is involved in the formation of these bone tumors.

MeSH Terms
Alleles Chromosome Mapping Chromosomes, Human, 13-15 DNA Restriction Enzymes Eye Neoplasms/genetics Genes, Recessive Homozygote Humans Neoplasms, Multiple Primary/genetics Osteosarcoma/genetics Retinoblastoma/genetics
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Dryja T P
Rapaport J M
Epstein J
Goorin A M
Weichselbaum R
Koufos A
Cavenee W K
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1986-01-00
Pages
59-66
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684712
Subset
IM
Grants
NCI NIH HHS · CA29883 · United States
NEI NIH HHS · EY05321 · United States
NEI NIH HHS · EY05510 · United States
External Links
PubMed source PMC Full Text View journal details
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