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PMID: 3001311 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.

Journal of medical genetics ·Vol. 22 ·No. 6 ·1985-12-00 ·Pages 447-50

Harper PS, Youngman S, Anderson MA, Sarfarazi M, Quarrell O, Tanzi R, Shaw D, Wallace P, Conneally PM, Gusella JF

Abstract

Analysis of the polymorphism shown by the DNA probe G8 in eight South Wales families with Huntington's disease has confirmed close genetic linkage between this marker and the disorder, the most likely genetic distance being two centimorgans (cM). The closeness of the linkage suggests that G8 may have clinical applications in genetic prediction for this condition.

MeSH Terms
Chromosome Mapping Cloning, Molecular DNA/genetics DNA Restriction Enzymes/genetics Genetic Linkage Genotype Humans Huntington Disease/genetics Pedigree Polymorphism, Genetic Wales
Chemicals
DNA DNA Restriction Enzymes
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Harper P S
Youngman S
Anderson M A
Sarfarazi M
Quarrell O
Tanzi R
Shaw D
Wallace P
Conneally P M
Gusella J F
References (6)
6 references, click to expand
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    Am J Hum Genet. 1974 Sep;26(5):588-97 PMID: 4422075
  2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  3. DNA markers for nervous system diseases.
    Science. 1984 Sep 21;225(4668):1320-6 PMID: 6089346
  4. A life table for onset of Huntington's chorea.
    Ann Hum Genet. 1981 Oct;45(Pt 4):375-85 PMID: 6211128
  5. A genetic register for Huntington's chorea in South Wales.
    J Med Genet. 1982 Aug;19(4):241-5 PMID: 6214632
  6. Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):1245-9 PMID: 265567
Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.22.6.447
Published
1985-12-00
Pages
447-50
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1049504
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.22.6.447 PMC Full Text View journal details
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