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PMID: 2997640 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics.

Neurochemical research ·Vol. 10 ·No. 8 ·1985-08-00 ·Pages 1019-24

Van Rooijen LA, Agranoff BW

Abstract

The calcium-activated phosphodiesteratic hydrolysis of 32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasing concentrations of Ca2+, indicating that the aminoglycosides exert their effect by displacing Ca2+ from lipid.

MeSH Terms
Aminoglycosides/pharmacology Animals Anti-Bacterial Agents/pharmacology Calcium/metabolism,pharmacology Gentamicins/pharmacology In Vitro Techniques Membranes/drug effects,metabolism Neomycin/pharmacology Nerve Endings/drug effects,metabolism Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates Phosphatidylinositols/metabolism Phosphodiesterase Inhibitors Phosphoinositide Phospholipase C Phosphoric Diester Hydrolases Streptomycin/pharmacology
Chemicals
Aminoglycosides Anti-Bacterial Agents Gentamicins Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates Phosphatidylinositols Phosphodiesterase Inhibitors phosphatidylinositol 4-phosphate Phosphoric Diester Hydrolases Phosphoinositide Phospholipase C Neomycin Calcium Streptomycin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Van Rooijen L A
Agranoff B W
References (17)
17 references, click to expand
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF00965878
Published
1985-08-00
Pages
1019-24
Language
English
Region
United States
NLM ID
7613461
Subset
IM
Grants
NINDS NIH HHS · NS 15413 · United States
External Links
PubMed source DOI: 10.1007/BF00965878 View journal details
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