Prolonged influence of a single neonatal steroid (dexamethasone) treatment on thymocytic steroid binding.

Experimental and clinical endocrinology ·Vol. 85 ·No. 3 ·1985-06-00 ·Pages 358-60

Inczefi-Gonda A, Csaba G

Abstract

Treatment of newborn rats with a single low dose of dexamethasone gave rise to lasting alteration of thymocytic receptor binding capacity. The receptors decreased markedly in number, while their affinity for the hormone was slightly increased. It appears that imprinting with a steroid changes the receptor--hormone relationship in the adult organism.

MeSH Terms

Animals Animals, Newborn Dexamethasone/pharmacology Female Male Rats Receptors, Cell Surface/drug effects,metabolism Thymus Gland/drug effects,metabolism

Chemicals

Receptors, Cell Surface Dexamethasone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Inczefi-Gonda A

Csaba G

Article Info

Journal

Experimental and clinical endocrinology

Abbr.

Exp Clin Endocrinol

ISSN

0232-7384

DOI

10.1055/s-0029-1210462

Published

1985-06-00

Pages

358-60

Language

English

Region

Germany

NLM ID

8302802

Subset

External Links

PubMed source DOI: 10.1055/s-0029-1210462

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Prolonged influence of a single neonatal steroid (dexamethasone) treatment on thymocytic steroid binding.

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