Home LiteratureArticle Details
PMID: 2993470 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Growth factor-mediated tumor cell proliferation in hairy cell leukemia.

The Journal of experimental medicine ·Vol. 162 ·No. 3 ·1985-09-01 ·Pages 1093-8

Ford RJ, Yoshimura L, Morgan J, Quesada J, Montagna R, Maizel A

Abstract

Leukemic B cells from seven patients with hairy cell leukemia (HCL), six of which contained the Tac antigen, were assayed in vitro for growth factor-mediated cell proliferation. The HCL cells showed typical phenotypic profiles by monoclonal antibody analysis. The tumor cells, which do not grow spontaneously in vitro, were found to proliferate in all but one case in response to partially purified B cell growth factor (BCGF) without anti-mu or Sac activation. Recombinant interleukin 2 however produced only a marginal response and could not support leukemic cell growth in vitro. BCGF, however, did stimulate in vitro cell growth and supported the establishment of continuous (greater than 60 d in vitro) in four of the seven HCL cases.

MeSH Terms
Antigens, Neoplasm/analysis Antigens, Surface/analysis B-Lymphocytes/drug effects,immunology,pathology Cell Division/drug effects Cells, Cultured Growth Substances/pharmacology Humans Interleukin-2/pharmacology Interleukin-4 Leukemia, Hairy Cell/pathology Lymphocyte Activation/drug effects Lymphokines/pharmacology Tumor Necrosis Factor Receptor Superfamily, Member 7
Chemicals
Antigens, Neoplasm Antigens, Surface Growth Substances Interleukin-2 Lymphokines Tumor Necrosis Factor Receptor Superfamily, Member 7 Interleukin-4
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ford R J
Yoshimura L
Morgan J
Quesada J
Montagna R
Maizel A
References (15)
15 references, click to expand
  1. Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis.
    N Engl J Med. 1971 Feb 18;284(7):357-60 PMID: 5275977
  2. The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia.
    Blood. 1985 Apr;65(4):974-83 PMID: 3978236
  3. Soluble factor activation of human B lymphocytes.
    Nature. 1981 Nov 19;294(5838):261-3 PMID: 6795510
  4. Monoclonal antibodies with specificity for hairy cell leukemia cells.
    J Clin Invest. 1982 Aug;70(2):254-61 PMID: 7047565
  5. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.
    Nature. 1982 Nov 18;300(5889):267-9 PMID: 6815536
  6. Proliferation of human B lymphocytes mediated by a soluble factor.
    Fed Proc. 1983 Jul;42(10):2753-6 PMID: 6602720
  7. Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.
    Proc Natl Acad Sci U S A. 1983 Jul;80(14):4522-6 PMID: 6192435
  8. Long-term growth of human B cells and their use in a microassay for B-cell growth factor.
    Proc Natl Acad Sci U S A. 1983 Aug;80(16):5047-51 PMID: 6603621
  9. Biochemical separation of a human B cell mitogenic factor.
    Proc Natl Acad Sci U S A. 1982 Oct;79(19):5998-6002 PMID: 6985268
  10. Biological activity of recombinant human interleukin-2 produced in Escherichia coli.
    Science. 1984 Mar 30;223(4643):1412-4 PMID: 6367046
  11. Control of human lymphocyte proliferation by soluble factors.
    Lab Invest. 1984 Apr;50(4):369-77 PMID: 6423891
  12. Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.
    J Exp Med. 1984 Oct 1;160(4):1126-46 PMID: 6090574
  13. Detection and functional studies of p60-65 (Tac antigen) on activated human B cells.
    J Exp Med. 1984 Nov 1;160(5):1597-602 PMID: 6092512
  14. Interleukin 2 regulates its own receptors.
    Proc Natl Acad Sci U S A. 1985 Feb;82(3):864-8 PMID: 2983318
  15. Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.
    J Immunol. 1980 Aug;125(2):725-31 PMID: 6993560
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.3.1093
Published
1985-09-01
Pages
1093-8
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187808
Subset
IM
Grants
NCI NIH HHS · CA-16672 · United States
NCI NIH HHS · CA-31479 · United States
External Links
PubMed source DOI: 10.1084/jem.162.3.1093 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2