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PMID: 2991504 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The role of cyclic nucleotides in modulation of the membrane potential of the Schwann cell of squid giant nerve fibre.

The Journal of physiology ·Vol. 363 ·1985-06-00 ·Pages 151-67

Evans PD, Reale V, Villegas J

Abstract

The role of cyclic nucleotides in mediating the effects of nicotine cholinergic receptors has been investigated in Schwann cells of the giant nerve fibre of the squid. Elevation of cyclic AMP levels in this preparation by means of the phosphodiesterase inhibitor, theophylline, by the diterpene adenylate cyclase activator, forskolin, and by cyclic nucleotide analogues mimics the action of activating the nicotinic cholinergic receptors in producing a long-lasting hyperpolarization of the membrane potential of the Schwann cell. Theophylline and forskolin also potentiate the effects of carbachol and of neural stimulation on the Schwann cell. The results suggest that the nicotinic receptor of the squid Schwann cell is likely to mediate its effects via a mechanism that activates adenylate cyclase. The results are discussed in terms of the role of cyclic AMP in the complex multistep interaction between the giant axon of the squid and its surrounding Schwann-cell layer.

MeSH Terms
Adenylyl Cyclase Inhibitors Animals Axons/physiology Bucladesine/pharmacology Carbachol/pharmacology Colforsin Cyclic AMP/analogs & derivatives,pharmacology Decapodiformes Diterpenes/pharmacology In Vitro Techniques Membrane Potentials/drug effects Phosphodiesterase Inhibitors/pharmacology Receptors, Cholinergic/drug effects Schwann Cells/physiology Theophylline/pharmacology Thionucleotides/pharmacology
Chemicals
Adenylyl Cyclase Inhibitors Diterpenes Phosphodiesterase Inhibitors Receptors, Cholinergic Thionucleotides Colforsin 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP Bucladesine Carbachol Theophylline Cyclic AMP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Evans P D
Reale V
Villegas J
References (30)
30 references, click to expand
  1. Effects of acetylcholine and carbamylcholine on the axon and Schwann cell electrical potentials in the squid nerve fibre.
    J Physiol. 1974 Nov;242(3):647-59 PMID: 4449050
  2. Effects of tubocurarine and eserine on the axon-Schwann cell relationship in the squid nerve fibre.
    J Physiol. 1973 Jul;232(1):193-208 PMID: 4733485
  3. Characterization of acetylcholine receptors in the Schwann cell membrane of the squid nerve fibre.
    J Physiol. 1975 Aug;249(3):679-89 PMID: 1177111
  4. Grayanotoxin, veratrine, and tetrodotoxin-sensitive sodium pathways in the Schwann cell membrane of squid nerve fibers.
    J Gen Physiol. 1976 Mar;67(3):369-80 PMID: 1262854
  5. Targets of octopamine action in the lobster: cyclic nucleotide changes and physiological effects in hemolymph, heart and exoskeletal muscle.
    J Pharmacol Exp Ther. 1978 May;205(2):438-48 PMID: 347053
  6. Acetylcholine content of the Schwann cell and axon in the giant nerve fibre of the squid.
    J Neurochem. 1979 Mar;32(3):761-6 PMID: 430056
  7. Environmental determination of autonomic neurotransmitter functions.
    Annu Rev Neurosci. 1978;1:1-17 PMID: 40525
  8. A comparative survey of the function, mechanism and control of cellular oscillators.
    J Exp Biol. 1979 Aug;81:217-79 PMID: 390080
  9. Acetylcholine synthesis in the Schwann cell and axon in the giant nerve fiber of the squid.
    J Neurochem. 1981 Feb;36(2):765-8 PMID: 7463090
  10. Forskolin: a unique diterpene activator of cyclic AMP-generating systems.
    J Cyclic Nucleotide Res. 1981;7(4):201-24 PMID: 6278005
  11. Axon/Schwann-cell relationships in the giant nerve fibre of the squid.
    J Exp Biol. 1981 Dec;95:135-51 PMID: 7334317
  12. Macromolecular transfer from glia to the axon.
    J Exp Biol. 1981 Dec;95:153-65 PMID: 6174660
  13. Glial versus neuronal uptake of glutamate.
    J Exp Biol. 1981 Dec;95:181-93 PMID: 6120988
  14. Effect of non-neuronal cells on peptide content of cultured sensory neurones.
    J Exp Biol. 1981 Dec;95:195-203 PMID: 6174661
  15. Transmitter status in cultured rat sympathetic neurons: plasticity and multiple function.
    Fed Proc. 1983 Apr;42(6):1626-32 PMID: 6131842
  16. cAMP-dependent protein kinase phosphorylates the nicotinic acetylcholine receptor.
    Proc Natl Acad Sci U S A. 1983 Feb;80(4):1130-4 PMID: 6302672
  17. Neuropeptides modulate the beta-adrenergic response of purified astrocytes in vitro.
    Nature. 1983 Oct 20-26;305(5936):715-7 PMID: 6195528
  18. A modulatory octopaminergic neurone increases cyclic nucleotide levels in locust skeletal muscle.
    J Physiol. 1984 Mar;348:307-24 PMID: 6201609
  19. The role of cyclic nucleotides and calcium in the mediation of the modulatory effects of octopamine on locust skeletal muscle.
    J Physiol. 1984 Mar;348:325-40 PMID: 6201610
  20. Role for microsomal Ca storage in mammalian neurones?
    Nature. 1984 May 10-16;309(5964):158-60 PMID: 6717595
  21. Forskolin, adenylate cyclase, and cell physiology: an overview.
    Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:81-9 PMID: 6328947
  22. Interaction of forskolin with dually regulated adenylate cyclase.
    Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:91-9 PMID: 6328948
  23. Inositol trisphosphate and diacylglycerol as second messengers.
    Biochem J. 1984 Jun 1;220(2):345-60 PMID: 6146314
  24. Calcium-dependent enhancement by carbachol of the VIP-induced cyclic AMP accumulation in cat submandibular gland.
    Acta Physiol Scand. 1984 Apr;120(4):523-8 PMID: 6091414
  25. A calcium-activated cation-selective channel in rat cultured Schwann cells.
    Proc R Soc Lond B Biol Sci. 1984 Sep 22;222(1228):349-55 PMID: 6149556
  26. The after-effects of impulses in the giant nerve fibres of Loligo.
    J Physiol. 1956 Feb 28;131(2):341-76 PMID: 13320339
  27. The physiology of neuroglial cells.
    Ergeb Physiol. 1966;57:1-90 PMID: 5330861
  28. Changes in extracellular potassium concentration produced by neuronal activity in the central nervous system of the leech.
    J Physiol. 1969 Aug;203(3):555-69 PMID: 5387026
  29. Axon-Schwann cell interaction in the squid nerve fibre.
    J Physiol. 1972 Sep;225(2):275-96 PMID: 5074387
  30. Induction of hepatic tyrosine aminotransferase in vivo by derivatives of cyclic adenosine 3':5'-monophosphate.
    J Biol Chem. 1975 Jan 25;250(2):426-31 PMID: 234951
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1985.sp015701
Published
1985-06-00
Pages
151-67
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1192920
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1985.sp015701 PMC Full Text View journal details
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