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PMID: 2990983 Published · ppublish English Journal Article

The cholinergic innervation of the visual thalamus: an EM immunocytochemical study.

Experimental brain research ·Vol. 59 ·No. 1 ·1985-00-00 ·Pages 206-12

de Lima AD, Montero VM, Singer W

Abstract

In this study we demonstrate at the ultrastructural level that both the dorsal lateral geniculate nucleus (dLGN), the visual relay of the thalamus, and the perigeniculate nucleus (PGN), the visual segment of the thalamic reticular nucleus (TRN), are densely innervated by fibres with Choline-Acetyl-Transferase (ChAT) like immunoreactivity. These axons make synaptic contacts with interneurones considered to be inhibitory, both in the PGN and within the synaptic glomeruli of the dLGN. In addition, Chat positive terminals form intra- and extraglomerular synapses with dendrites thought to arise from relay cells. We interpret these results as evidence for direct cholinergic modulation of both relay cells and inhibitory interneurones.

MeSH Terms
Animals Cats Choline O-Acetyltransferase/metabolism Cholinergic Fibers/ultrastructure Geniculate Bodies/enzymology,ultrastructure Microscopy, Electron Synapses/enzymology Synaptic Transmission Thalamic Nuclei/enzymology,physiology,ultrastructure Visual Pathways/enzymology
Chemicals
Choline O-Acetyltransferase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
de Lima A D
Montero V M
Singer W
References (33)
33 references, click to expand
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00237681
Published
1985-00-00
Pages
206-12
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00237681 View journal details
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