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PMID: 2989824 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Close linkage of alpha and beta interferons and infrequent duplication of beta interferon in humans.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 13 ·1985-07-00 ·Pages 4473-6

Ohlsson M, Feder J, Cavalli-Sforza LL, von Gabain A

Abstract

Five restriction fragment length polymorphisms in the human alpha/beta interferon (IFN-alpha/beta) gene region were identified, three with an IFN-alpha probe and two with an IFN-beta probe. Heterozygosities are 74% for IFN-alpha, 57% for IFN-beta, and 87% jointly, making IFN-alpha/beta genes excellent markers for the short arm of chromosome 9. The pedigrees of about 25 families of Caucasian background were studied. Segregation analysis disclosed the occurrence of 12 of 32 possible haplotypes. No recombinant was found between IFN-alpha and -beta genetic markers; linkage disequilibrium within the IFN-alpha markers is of a similar order of magnitude as that between the IFN-alpha and -beta markers. The IFN-alpha and -beta genes might cluster within several hundred kilobases. In two parents, the IFN-beta gene is duplicated; the duplications segregate regularly. They are of independent, probably recent, origin. Therefore, some degree of multiplicity might even be found for IFN-beta, at least in some individuals.

MeSH Terms

Adult Child DNA/analysis DNA Restriction Enzymes/metabolism Electrophoresis, Agar Gel Female Genetic Linkage Haploidy Humans Interferon Type I/genetics Male Molecular Weight Polymorphism, Genetic

Chemicals

Interferon Type I DNA DNA Restriction Enzymes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ohlsson M

Feder J

Cavalli-Sforza L L

von Gabain A

References (9)

9 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.82.13.4473

Published

1985-07-00

Pages

4473-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC391123

Subset

Grants

NIGMS NIH HHS · GM 20467 · United States

NIGMS NIH HHS · GM 28428 · United States

External Links

PubMed source DOI: 10.1073/pnas.82.13.4473 PMC Full Text View journal details

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Close linkage of alpha and beta interferons and infrequent duplication of beta interferon in humans.

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