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PMID: 2985506 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of growth of Chlamydia trachomatis by human gamma interferon.

Infection and immunity ·Vol. 48 ·No. 2 ·1985-05-00 ·Pages 592-6

Shemer Y, Sarov I

Abstract

Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (greater than 350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.

MeSH Terms

Cell Line Chlamydia trachomatis/growth & development,ultrastructure Humans Inclusion Bodies/ultrastructure Interferon-gamma/pharmacology Microscopy, Electron

Chemicals

Interferon-gamma

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Shemer Y

Sarov I

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.48.2.592-596.1985

Published

1985-05-00

Pages

592-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC261392

Subset

External Links

PubMed source DOI: 10.1128/iai.48.2.592-596.1985 PMC Full Text View journal details

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Inhibition of growth of Chlamydia trachomatis by human gamma interferon.

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