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PMID: 2964639 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 85 ·No. 6 ·1988-03-00 ·Pages 1888-92

Iuchi S, Lin EC

Abstract

In Escherichia coli the levels of numerous enzymes associated with aerobic metabolism are decreased during anaerobic growth. In an arcA mutant the anaerobic levels of these enzymes are increased. The enzymes, which are encoded by different regulons, include members that belong to the tricarboxylic acid cycle, the glyoxylate shunt, the pathway for fatty acid degradation, several dehydrogenases of the flavoprotein class, and the cytochrome o oxidase complex. Transductional crosses placed the arcA gene near min O on the chromosomal map. Complementation tests showed that the arcA gene corresponded to the dye gene, which is also known as fexA, msp, seg, or sfrA because of various phenotypic properties [Bachmann, B. (1983) Microbiol. Rev. 47, 180-230]. A dye-deletion mutant was derepressed in the aerobic enzyme system. The term modulon is proposed to describe a set of regulons that are subject to a common transcriptional control.

MeSH Terms
Aerobiosis Chromosome Mapping Escherichia coli/enzymology,genetics Gene Expression Regulation Genes, Bacterial Genes, Regulator Genes, araC Mutation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Iuchi S
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
Lin E C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.85.6.1888
Published
1988-03-00
Pages
1888-92
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC279886
Subset
IM
Grants
NIGMS NIH HHS · 5-R01-GM11983 · United States
External Links
PubMed source DOI: 10.1073/pnas.85.6.1888 PMC Full Text View journal details
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