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PMID: 2943662 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization.

Human genetics ·Vol. 73 ·No. 4 ·1986-08-00 ·Pages 354-7

Landegent JE, Jansen in de Wal N, Fisser-Groen YM, Bakker E, van der Ploeg M, Pearson PL

Abstract

The chromosomal localization of a unique DNA fragment, closely linked to Huntington disease (HD), was assessed in situ by hybridization with 2-acetylaminofluorene (AAF) modified probes. In these experiments, a cosmid cloned genomic fragment (c5.5) was used for hybridization. Here we present evidence that confirms the mapping of the D4S10 locus to the p16 region of chromosome 4 and assigns it to the telomere of the short arm.

MeSH Terms

Chromosome Mapping DNA/genetics Genetic Linkage Genetic Markers Humans Huntington Disease/genetics Karyotyping Lymphocytes/ultrastructure Nucleic Acid Hybridization

Chemicals

Genetic Markers DNA

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Landegent J E

Jansen in de Wal N

Fisser-Groen Y M

Bakker E

van der Ploeg M

Pearson P L

References (12)

12 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00279100

Published

1986-08-00

Pages

354-7

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00279100 View journal details

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Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization.

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