Comparative in vitro activity of seven quinolones against 100 clinical isolates of Clostridium difficile.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 2 ·1986-02-00 ·Pages 374-5

Delmee M, Avesani V

Abstract

The in vitro activity of seven quinolone derivatives against 100 clinical isolates of Clostridium difficile was determined. CI934 was the most active, inhibiting 90% of the strains at 4 micrograms/ml and 100% at 8 micrograms/ml. Ofloxacin and ciprofloxacin had moderate activity (16 and 32 micrograms/ml) whereas enoxacin, pefloxacin, norfloxacin, and nalidixic acid had poor activity (128 micrograms/ml).

MeSH Terms

Anti-Bacterial Agents/pharmacology Child Ciprofloxacin Clostridium/classification,drug effects Enoxacin Fluoroquinolones Humans Infant, Newborn Microbial Sensitivity Tests Nalidixic Acid/pharmacology Naphthyridines/pharmacology Norfloxacin/analogs & derivatives,pharmacology Ofloxacin Oxazines/pharmacology Pefloxacin Quinolines/pharmacology

Chemicals

Anti-Bacterial Agents Fluoroquinolones Naphthyridines Oxazines Quinolines Pefloxacin Enoxacin Nalidixic Acid Ciprofloxacin CI 934 Ofloxacin Norfloxacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Delmee M

Avesani V

References (10)

10 references, click to expand

In vitro activity of ciprofloxacin compared with those of other new fluorinated piperazinyl-substituted quinoline derivatives.
Antimicrob Agents Chemother. 1984 Apr;25(4):518-21 PMID: 6732221
Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.
Antimicrob Agents Chemother. 1984 Jul;26(1):110-1 PMID: 6236745
Serogrouping of Clostridium difficile strains by slide agglutination.
J Clin Microbiol. 1985 Mar;21(3):323-7 PMID: 3980688
Comparative activity of ciprofloxacin against anaerobic bacteria.
Antimicrob Agents Chemother. 1985 Mar;27(3):427-8 PMID: 3158278
Comparative in vitro activity of ciprofloxacin against Campylobacter spp. and other bacterial enteric pathogens.
Antimicrob Agents Chemother. 1984 Apr;25(4):504-6 PMID: 6732220
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.
N Engl J Med. 1978 Mar 9;298(10):531-4 PMID: 625309
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
Br Med J. 1978 Mar 18;1(6114):695 PMID: 630301
Collaborative evaluation of a proposed reference dilution method of susceptibility testing of anaerobic bacteria.
Antimicrob Agents Chemother. 1979 Oct;16(4):495-502 PMID: 518079
In vitro susceptibility of Clostridium difficile isolates from patients with antibiotic-associated diarrhea or colitis.
Antimicrob Agents Chemother. 1980 Apr;17(4):695-8 PMID: 7396460
Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals.
Antimicrob Agents Chemother. 1985 Apr;27(4):657-9 PMID: 3847273

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.29.2.374

Published

1986-02-00

Pages

374-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC176416

Subset

External Links

PubMed source DOI: 10.1128/AAC.29.2.374 PMC Full Text View journal details

Analysis Services

Comparative in vitro activity of seven quinolones against 100 clinical isolates of Clostridium difficile.

Contact

WeChat Official Account