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PMID: 293721 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hyaluronate and invasiveness of the rabbit V2 carcinoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 12 ·1979-12-00 ·Pages 6299-303

Toole BP, Biswas C, Gross J

Abstract

We propose that hyaluronate, a major component of extracellular matrices through which cells migrate during embryonic tissue development and in regenerative processes, is also concentrated in the environment through which neoplastic cells invade local host tissues and may facilitate this process. The hyaluronate content of invasive V2 carcinoma grown in rabbit was found to be 3-4 times greater than that of the same tumor grown in the nude mouse, in which it is noninvasive. Moreover, hyaluronate concentrations were most elevated in the connective tissue interface between the tumor mass and the neighboring host tissue in the invasive rabbit tumors. The particular site of tumor implantation in the rabbit or nude mouse did not affect the concentrations of hyaluronate in either the parenchyma or the surrounding connective tissue. Similar values were obtained for neoplasms grown in muscle, which normally contains little hyaluronate, and in subcutaneous tissue, which is relatively rich in this glycosaminoglycan.

MeSH Terms
Animals Carcinoma/metabolism,pathology Cell Movement Connective Tissue/metabolism Extracellular Space/physiology Glycosaminoglycans/metabolism Hyaluronic Acid/metabolism Mice Mice, Nude/metabolism Neoplasm Transplantation Neoplasms, Experimental/metabolism,pathology Rabbits
Chemicals
Glycosaminoglycans Hyaluronic Acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Toole B P
Biswas C
Gross J
References (44)
44 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.12.6299
Published
1979-12-00
Pages
6299-303
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411851
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.12.6299 PMC Full Text View journal details
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