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PMID: 2934555 Published · ppublish English Journal Article

Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells.

Journal of virology ·Vol. 57 ·No. 1 ·1986-01-00 ·Pages 362-6

McMahon M, Stark GR, Kerr IM

Abstract

Interferon-induced gene expression was analyzed in wild-type and interferon-resistant Daudi cells. Two classes of alpha-interferon-induced mRNAs and proteins were observed: those that were similarly induced in both types of cell and those that were induced only in the wild-type cells. Furthermore, the level of c-myc mRNA decreased in the wild-type but not in the resistant cells. This differential control in the wild-type and resistant cells indicates that there must be either functionally distinct alpha-interferon receptors or more than one pathway leading to altered gene expression triggered by a single receptor.

MeSH Terms
Cell Division/drug effects Cell Line Drug Resistance Gene Expression Regulation/drug effects Humans Interferon Type I/pharmacology Lymphocytes/drug effects Protein Biosynthesis Proto-Oncogene Proteins/biosynthesis RNA, Messenger/biosynthesis Receptors, Immunologic/physiology Receptors, Interferon
Chemicals
Interferon Type I Proto-Oncogene Proteins RNA, Messenger Receptors, Immunologic Receptors, Interferon
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McMahon M
Stark G R
Kerr I M
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21 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.57.1.362-366.1986
Published
1986-01-00
Pages
362-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC252737
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.57.1.362-366.1986 PMC Full Text View journal details
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