A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.

Biochemical and biophysical research communications ·Vol. 158 ·No. 1 ·1989-01-16 ·Pages 348-52

Palmer RM, Moncada S

Abstract

An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by NG-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.

MeSH Terms

Animals Aorta, Thoracic Arginine/metabolism Cells, Cultured Citrulline/biosynthesis Endothelium, Vascular/enzymology Nitric Oxide/metabolism Swine

Chemicals

Citrulline Nitric Oxide Arginine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Palmer R M

Wellcome Research Laboratories, Langley Court, Beckenham, U.K.

Moncada S

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1016/s0006-291x(89)80219-0

Published

1989-01-16

Pages

348-52

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1016/s0006-291x(89)80219-0 View journal details

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A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells.

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