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PMID: 2903072 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15.

FEBS letters ·Vol. 239 ·No. 2 ·1988-11-07 ·Pages 185-9

Ashcroft FM, Ashcroft SJ, Berggren PO, Betzholz C, Rorsman P, Trube G, Welsh M

Abstract

Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting cell line HIT T15. One of these was the ATP-regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca-activated K channel from beta-cells.

MeSH Terms

Animals Calcium/pharmacology Cell Line Cell Membrane/drug effects,physiology Female Insulin/metabolism Insulin Secretion Islets of Langerhans/metabolism Membrane Potentials/drug effects Oocytes/physiology Poly A/genetics Potassium Channels/physiology Protein Biosynthesis RNA, Messenger/genetics Tolbutamide/pharmacology Xenopus laevis

Chemicals

Insulin Potassium Channels RNA, Messenger Poly A Tolbutamide Calcium

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Ashcroft F M

University Laboratory of Physiology, Oxford, England.

Ashcroft S J

Berggren P O

Betzholz C

Rorsman P

Trube G

Welsh M

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(88)80913-x

Published

1988-11-07

Pages

185-9

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(88)80913-x View journal details

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Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15.

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