Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.

Neuropharmacology ·Vol. 27 ·No. 6 ·1988-06-00 ·Pages 653-6

Danysz W, Wroblewski JT, Costa E

Abstract

2-Amino-5-phosphonovalerate (APV, icv) phencyclidine (PCP, ip) and scopolamine (sc) dose-dependently disrupted short term working memory in radial maze. These drugs injected before, but not after training attenuated retention of long term memory in passive avoidance task. A relation of PCP action to its antagonism at NMDA receptors may be suggested.

MeSH Terms

2-Amino-5-phosphonovalerate Animals Anticonvulsants/administration & dosage,pharmacology Avoidance Learning/drug effects Injections, Intraventricular Learning/drug effects Male Phencyclidine/pharmacology Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/drug effects Scopolamine/pharmacology Valine/administration & dosage,analogs & derivatives,pharmacology

Chemicals

Anticonvulsants Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter 2-Amino-5-phosphonovalerate Scopolamine Valine Phencyclidine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Danysz W

Fidia-Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, Washington, D.C. 20007.

Wroblewski J T

Costa E

Article Info

Journal

Neuropharmacology

Abbr.

Neuropharmacology

ISSN

0028-3908

DOI

10.1016/0028-3908(88)90189-x

Published

1988-06-00

Pages

653-6

Language

English

Region

England

NLM ID

0236217

Subset

External Links

PubMed source DOI: 10.1016/0028-3908(88)90189-x View journal details

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Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.

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