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PMID: 2895681 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Polyclonal lymphocytosis of T-cells associated with human T-cell leukemia virus I.

Cancer research ·Vol. 48 ·No. 9 ·1988-05-01 ·Pages 2585-9

Posnett DN, McGrath HA, Scott RA, McNutt NS, Folkl R, Hickey TD, Macera MJ, Szabo P

Abstract

A patient with antibodies to human T-cell leukemia virus type I and the presence of integrated sequences of this virus in T-lymphocytes was investigated. In contrast to previous reports, the T-cell lymphocytosis was found to be polyclonal by analysis of human T-cell leukemia virus type I integration sites and T-cell antigen receptor rearrangements. Polyclonal T-cell infection by human T-cell leukemia virus type I may represent an infrequently observed stage of leukemogenesis.

MeSH Terms

Aged DNA, Viral/analysis Deltaretrovirus/genetics Deltaretrovirus Infections/complications Female Humans Immunoglobulin Isotypes/analysis Leukemia/etiology Lymphocytosis/immunology,microbiology Proviruses/genetics Receptors, Antigen, T-Cell/genetics T-Lymphocytes/microbiology

Chemicals

DNA, Viral Immunoglobulin Isotypes Receptors, Antigen, T-Cell

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Posnett D N

Department of Medicine, Cornell University Medical College, New York, New York 10021.

McGrath H A

Scott R A

McNutt N S

Folkl R

Hickey T D

Macera M J

Szabo P

Article Info

Journal

Cancer research

Abbr.

Cancer Res

ISSN

0008-5472

Published

1988-05-01

Pages

2585-9

Language

English

Region

United States

NLM ID

2984705R

Subset

Grants

NCI NIH HHS · CA 35473 · United States

NCI NIH HHS · CA 40192 · United States

External Links

PubMed source View journal details

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Polyclonal lymphocytosis of T-cells associated with human T-cell leukemia virus I.

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