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题目:: Proliferation, senescence, and neoplastic progression of beta cells in hyperplasic pancreatic islets.
作者:: Teitelman(G),Alpert(S),Hanahan(D)
状态:: 发布时间1988-04-14 , 更新时间 2011-11-17
期刊:: Cell
摘要:: Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in contrast to the "insulin-only" cells. In later stages the number of proliferating insulin-only cells decreases concomitant with an increase in the number of nondividing TH-insulin cells, suggesting that the TH-insulin cells are on a pathway to senescence. In the presence of an oncoprotein the TH-insulin cells are able to proliferate. The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
语言:: eng
DOI:

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