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PMID: 2890478 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

GABA binding in bovine adrenal medulla membranes is sensitive to baclofen.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology ·Vol. 88 ·No. 1 ·1987-00-00 ·Pages 155-7

Martinez P, Gimenez A, Castro E, Oset-Gasque MJ, Cañadas S, González MP

Abstract

1. The data summarized in this report reveals the existence of GABA binding in the bovine adrenal medulla membranes. 2. Since this binding was displaced not only by muscimol and bicuculline but also by baclofen, results suggest the possibility that both types of receptors (GABAA and GABAB) could be present in bovine adrenal membranes.

MeSH Terms

Adrenal Medulla/metabolism Animals Baclofen/pharmacology Bicuculline/pharmacology Cattle Cell Membrane/metabolism Kinetics Muscimol/pharmacology Receptors, GABA-A/drug effects,metabolism gamma-Aminobutyric Acid/metabolism

Chemicals

Receptors, GABA-A Muscimol gamma-Aminobutyric Acid Baclofen Bicuculline

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Martinez P

Instituto de Bioquímica, Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.

Gimenez A

Castro E

Oset-Gasque M J

Cañadas S

González M P

Article Info

Journal

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

Abbr.

Comp Biochem Physiol C Comp Pharmacol Toxicol

ISSN

0742-8413

DOI

10.1016/0742-8413(87)90060-0

Published

1987-00-00

Pages

155-7

Language

English

Region

England

NLM ID

8310013

Subset

External Links

PubMed source DOI: 10.1016/0742-8413(87)90060-0

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GABA binding in bovine adrenal medulla membranes is sensitive to baclofen.

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