Hormonal control of pancreatic cancer growth.

Pancreas ·Vol. 1 ·No. 1 ·1986-00-00 ·Pages 44-8

Liebow C, Hierowski M, duSapin K

Abstract

The effects of epidermal growth factor (EGF) and somatostatin-14 (SS) on growth of Mia PaCa-2 cells in cell culture were examined. EGF had no effect on cell growth in sera containing media but significantly increased growth in sera-free media. The effect of EGF was complete within 18 h. SS added with EGF entirely eliminated the growth stimulation of EGF. SS added to cells in culture with sera inhibited their growth as well.

MeSH Terms

Cell Division/drug effects Cell Line Epidermal Growth Factor/pharmacology,physiology ErbB Receptors/drug effects,physiology Humans Neoplasms, Hormone-Dependent/drug therapy,pathology,physiopathology Pancreatic Neoplasms/drug therapy,pathology,physiopathology Somatostatin/pharmacology

Chemicals

Somatostatin Epidermal Growth Factor ErbB Receptors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Liebow C

Hierowski M

duSapin K

Article Info

Journal

Pancreas

Abbr.

Pancreas

ISSN

0885-3177

DOI

10.1097/00006676-198601000-00009

Published

1986-00-00

Pages

44-8

Language

English

Region

United States

NLM ID

8608542

Subset

External Links

PubMed source DOI: 10.1097/00006676-198601000-00009 View journal details

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