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PMID: 28789707 Published · epublish English Editorial Review Research Support, Non-U.S. Gov't

Checkpoint inhibitors in melanoma and early phase development in solid tumors: what's the future?

Journal of translational medicine ·Vol. 15 ·No. 1 ·2017-00-08 ·Pages 173

Ascierto PA, McArthur GA

Abstract

Anti-programmed death (PD)-1 and PD-ligand (L)-1 checkpoint inhibitors have revolutionized the therapy of several cancers. Immunotherapy of cancer can offer long-term durable benefit to patients, is active regardless of tumour histology, has a unique immune-related safety profile, and can be used in combination with other cancer treatments. In addition, recent research has shown that immune-based therapy can be used as adjuvant therapy, that outcomes may be influenced by dose, and that clinical activity is observed in patients with brain metastases. Despite our increased understanding of these agents, there are still several important questions that need to be answered. These include strategies to overcome primary and acquired resistance, the influence of mutational status on treatment outcomes, the optimal duration of treatment, and the need to identify novel combination regimens that offer increased anti-tumour potency and/or reduced toxicity. Here we review recent developments in these areas, with particular focus on new data reported at the 2017 ASCO Annual Meeting.

Keywords
Anti-PD-1 Anti-PD-L1 Combination therapy Immunotherapy Melanoma
MeSH Terms
Carcinogenesis/pathology Cell Cycle Checkpoints Drug Resistance, Neoplasm Humans Melanoma/drug therapy,genetics,pathology Mutation/genetics Skin Neoplasms/drug therapy,genetics,pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ascierto Paolo A
Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", Via Mariano Semmola, 80131, Naples, Italy. paolo.ascierto@gmail.com.
McArthur Grant A
Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. grant.mcarthur@petermac.org. | University of Melbourne, Parkville, VIC, Australia. grant.mcarthur@petermac.org.
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Article Info
Journal
Journal of translational medicine
Abbr.
J Transl Med
ISSN
1479-5876
Published
2017-00-08
Epub
2017-00-08
Pages
173
Language
English
Region
England
NLM ID
101190741
PMCID
PMC5549368
Subset
IM
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