Localisation of the gene for Hunter syndrome on the long arm of X chromosome.

Human genetics ·Vol. 74 ·No. 4 ·1986-12-00 ·Pages 391-8

Upadhyaya M, Sarfarazi M, Bamforth JS, Thomas NS, Oberle I, Young I, Harper PS

Abstract

The localisation of the gene for Hunter syndrome (MPS II) has been studied in 11 families using 12 polymorphic DNA markers, one on the short arm and the remaining 11 located at various points on the long arm of the X chromosome. Lod scores for seven probes were uniformly negative for all values of theta; positive scores at values of theta = 0.10 or more were obtained for the five probes located most distally on the long arm (52A, F9C, DX13, St14-1, F8C). Current data suggest the most likely order of the loci to be: 52A, F9C, Hunter, DX13, St14-1, F8C-qter; the Hunter locus may thus be close to that for the fragile site at Xq27.

MeSH Terms

Chromosome Banding Chromosome Mapping DNA/genetics Female Genetic Linkage Genetic Markers Humans Male Mucopolysaccharidosis II/genetics Pedigree Polymorphism, Restriction Fragment Length X Chromosome

Chemicals

Genetic Markers DNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Upadhyaya M

Sarfarazi M

Bamforth J S

Thomas N S

Oberle I

Young I

Harper P S

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21 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00280492

Published

1986-12-00

Pages

391-8

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00280492 View journal details

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Localisation of the gene for Hunter syndrome on the long arm of X chromosome.

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