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PMID: 2877942 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13).

Human genetics ·Vol. 74 ·No. 3 ·1986-11-00 ·Pages 320-2

Estivill X, Schmidtke J, Williamson R, Wainwright B

Abstract

The anonymous DNA fragment B79a, which had previously been located to chromosome 7cen-7q22, has been more accurately assigned to 7q22 by dosage analysis in a patient hemizygous for a deletion of that region. By examination of a panel of genomic DNAs from unrelated individuals, digested with a number of different restriction enzymes, we have identified two frequent RFLPs detected by B79a. This probe will be important in the analysis of cystic fibrosis which has been mapped to the region around 7q22.

MeSH Terms
Chromosome Mapping Chromosomes, Human, Pair 7 Cystic Fibrosis/diagnosis,genetics DNA/genetics DNA, Recombinant Genetic Markers Humans Polymorphism, Genetic Polymorphism, Restriction Fragment Length
Chemicals
DNA, Recombinant Genetic Markers DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Estivill X
Schmidtke J
Williamson R
Wainwright B
References (12)
12 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00282558
Published
1986-11-00
Pages
320-2
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00282558 View journal details
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