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PMID: 2873352 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Prenatal diagnosis of autosomal dominant polycystic kidney disease with a DNA probe.

Lancet (London, England) ·Vol. 2 ·No. 8497 ·1986-07-05 ·Pages 6-8

Reeders ST, Zerres K, Gal A, Hogenkamp T, Propping P, Schmidt W, Waldherr R, Dolata MM, Davies KE, Weatherall DJ

Abstract

A highly polymorphic DNA probe genetically linked to the locus of autosomal dominant polycystic kidney disease was used in linkage studies for prenatal diagnosis in a nine-week fetus at risk for the disease. The fetus was judged to have inherited the polycystic kidney disease mutation, and this was confirmed by microscopic examination of the fetal kidneys at necropsy.

MeSH Terms

Abortion, Therapeutic Adult Alleles Chorionic Villi/analysis Chromosome Mapping Chromosomes, Human, 16-18 DNA/analysis Female Genetic Carrier Screening Genetic Linkage Genetic Markers Globins/genetics Humans Male Middle Aged Polycystic Kidney Diseases/diagnosis,genetics Pregnancy Prenatal Diagnosis Risk

Chemicals

Genetic Markers Globins DNA

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Reeders S T

Zerres K

Gal A

Hogenkamp T

Propping P

Schmidt W

Waldherr R

Dolata M M

Davies K E

Weatherall D J

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(86)92557-2

Published

1986-07-05

Pages

6-8

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(86)92557-2 View journal details

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Prenatal diagnosis of autosomal dominant polycystic kidney disease with a DNA probe.

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