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PMID: 2869417 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

[3H]-domperidone labels only a single population of receptors which convert from high to low affinity for dopamine in rat brain.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 332 ·No. 1 ·1986-01-00 ·Pages 21-5

Grigoriadis D, Seeman P

Abstract

Dopamine recognized and competed for a single population of [3H]-domperidone-binding sites in rat striatum and olfactory tubercle when tested in the presence of sodium ions and guanine nucleotide [Gpp(NH)p]. In the absence of Na+ and Gpp(NH)p, however, dopamine recognized two components of [3H]-domperidone binding. Thus, [3H]-domperidone labelled only a single population of dopamine receptors (type D2) which fully converted from high to low affinity for dopamine. These results agree with those found previously using [3H]-spiperone and [3H]-YM-09151-2.

MeSH Terms
Animals Antipsychotic Agents/pharmacology Benzamides/pharmacology Binding, Competitive/drug effects Brain/metabolism Corpus Striatum/metabolism Domperidone/pharmacology Dopamine/metabolism In Vitro Techniques Kinetics Male Olfactory Bulb/metabolism Rats Rats, Inbred Strains Receptors, Dopamine/drug effects,metabolism Spiperone/pharmacology
Chemicals
Antipsychotic Agents Benzamides Receptors, Dopamine Spiperone Domperidone nemonapride Dopamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Grigoriadis D
Seeman P
References (17)
17 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00633192
Published
1986-01-00
Pages
21-5
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00633192 View journal details
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