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PMID: 2868340 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.

Lancet (London, England) ·Vol. 1 ·No. 8478 ·1986-02-22 ·Pages 411-4

Hatton CS, Peto TE, Bunch C, Pasvol G, Russell SJ, Singer CR, Edwards G, Winstanley P

Abstract

6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

MeSH Terms

Acute Disease Adult Agranulocytosis/chemically induced Amodiaquine/administration & dosage,adverse effects Drug Combinations/administration & dosage Drug Therapy, Combination Female Humans Leukocyte Count Malaria/prevention & control Male Middle Aged Neutropenia/chemically induced Proguanil/administration & dosage Retrospective Studies Sulfaguanidine/administration & dosage Sulfamethoxazole/administration & dosage Travel Trimethoprim/administration & dosage Trimethoprim, Sulfamethoxazole Drug Combination

Chemicals

Drug Combinations Sulfaguanidine Amodiaquine Trimethoprim, Sulfamethoxazole Drug Combination Trimethoprim Sulfamethoxazole Proguanil

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Hatton C S

Peto T E

Bunch C

Pasvol G

Russell S J

Singer C R

Edwards G

Winstanley P

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(86)92371-8

Published

1986-02-22

Pages

411-4

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(86)92371-8 View journal details

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Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria.

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