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PMID: 2863055 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

The effects of calcitonin, parathyroid hormone and prostaglandin E2 on cyclic AMP levels of isolated osteoclasts.

Comparative biochemistry and physiology. A, Comparative physiology ·Vol. 81 ·No. 3 ·1985-00-00 ·Pages 653-7

Ito MB, Schraer H, Gay CV

Abstract

Cyclic AMP (cAMP) levels were measured in both isolated and attached osteoclasts. The level of cAMP was 0.1 pmol/10(5) osteoclasts. No change in cAMP level of osteoclasts could be detected following calcitonin treatment. Parathyroid hormone (PTH) and prostaglandin E2 (PGE2) treatment stimulated cAMP production in proportion to alkaline phosphatase levels and divergent to acid phosphatase levels. This indicates that osteoblasts, not osteoclasts, were responsive to PTH and PGE2.

MeSH Terms

Acid Phosphatase/metabolism Alkaline Phosphatase/metabolism Animals Calcitonin/pharmacology Chick Embryo Cyclic AMP/metabolism Dinoprostone Kinetics Osteoclasts/drug effects,metabolism Parathyroid Hormone/pharmacology Prostaglandins E/pharmacology

Chemicals

Parathyroid Hormone Prostaglandins E Calcitonin Cyclic AMP Alkaline Phosphatase Acid Phosphatase Dinoprostone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ito M B

Schraer H

Gay C V

Article Info

Journal

Comparative biochemistry and physiology. A, Comparative physiology

Abbr.

Comp Biochem Physiol A Comp Physiol

ISSN

0300-9629

DOI

10.1016/0300-9629(85)91043-6

Published

1985-00-00

Pages

653-7

Language

English

Region

England

NLM ID

1276312

Subset

Grants

NIADDK NIH HHS · AM00617 · United States

NIADDK NIH HHS · AM20374 · United States

NIDCR NIH HHS · DE04345 · United States

External Links

PubMed source DOI: 10.1016/0300-9629(85)91043-6

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The effects of calcitonin, parathyroid hormone and prostaglandin E2 on cyclic AMP levels of isolated osteoclasts.

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