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PMID: 2852821 Published · ppublish English Journal Article

Low permeability of the blood-brain barrier to nanomolar concentrations of immunoreactive alpha-melanotropin.

Psychopharmacology ·Vol. 96 ·No. 2 ·1988-00-00 ·Pages 262-6

Wilson JF

Abstract

The permeability of the blood-brain barrier (BBB) to immunoreactive alpha-melanotropin (alpha-MSH) was quantified in rats pretreated with monosodium L-glutamic acid to deplete their CNS stores of endogenous alpha-MSH. The methodology, suitable for poorly permeable substances, monitored blood and brain tissue concentrations of alpha-MSH over 15 min following intravenous injection of 30 nmol synthetic alpha-MSH. Rate constants for entry of alpha-MSH into brain tissue were estimated from separate non-linear least-squares fits of connecting two- and one-compartment open models to plasma and extravascular brain tissue concentration data, respectively. Comparisons were made to rate constants measured similarly for 14C-inulin. The BBB had a low permeability to immunoreactive alpha-MSH, consistent with peptide penetrating the barrier by passive diffusion dependent upon the lipid solubility of the molecule.

MeSH Terms
Animals Blood Proteins/metabolism Blood-Brain Barrier Brain Chemistry/drug effects Female Iodine Radioisotopes Male Models, Biological Permeability Protein Binding Rats Rats, Inbred Strains Sodium Glutamate/pharmacology alpha-MSH/metabolism,pharmacokinetics
Chemicals
Blood Proteins Iodine Radioisotopes alpha-MSH Sodium Glutamate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Wilson J F
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, UK.
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00177572
Published
1988-00-00
Pages
262-6
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00177572 View journal details
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