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PMID: 2845979 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Saposin D: a sphingomyelinase activator.

Biochemical and biophysical research communications ·Vol. 156 ·No. 1 ·1988-10-14 ·Pages 403-10

Morimoto S, Martin BM, Kishimoto Y, O'Brien JS

Abstract

Saposin D, a newly discovered heat-stable, 10 kDa glycoprotein, was isolated from Gaucher spleen and purified to homogeneity. Chemical sequencing from its amino terminus demonstrated colinearity between its amino acid sequence and the deduced amino acid sequence of the fourth domain of prosaposin, the precursor of saposin proteins. Saposin D specifically stimulates acid sphingomyelinase but has no significant effect on the other hydrolases tested.

MeSH Terms
Enzyme Activation Female Gaucher Disease/metabolism Glucosylceramidase/metabolism Glycoproteins/isolation & purification,physiology Humans Kinetics Liver/enzymology Phosphoric Diester Hydrolases/metabolism Placenta/enzymology Pregnancy Saposins Sphingomyelin Phosphodiesterase/metabolism Spleen/metabolism alpha-Glucosidases/metabolism beta-Galactosidase/metabolism
Chemicals
Glycoproteins Saposins Phosphoric Diester Hydrolases Sphingomyelin Phosphodiesterase alpha-Glucosidases beta-Galactosidase Glucosylceramidase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Morimoto S
Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla 92093.
Martin B M
Kishimoto Y
O'Brien J S
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1016/s0006-291x(88)80855-6
Published
1988-10-14
Pages
403-10
Language
English
Region
United States
NLM ID
0372516
Subset
IM
Grants
NICHD NIH HHS · HD-18983 · United States
NINDS NIH HHS · NS-08682 · United States
NINDS NIH HHS · NS-13559 · United States
External Links
PubMed source DOI: 10.1016/s0006-291x(88)80855-6 View journal details
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