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PMID: 2839456 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The respiratory burst oxidase.

Hematology/oncology clinics of North America ·Vol. 2 ·No. 2 ·1988-06-00 ·Pages 201-12

Babior BM

Abstract

The respiratory burst oxidase is an activatable, membrane-bound flavo(?hemo) protein that catalyzes the NADPH-dependent reduction of oxygen to superoxide (O2-) in stimulated phagocytes. Chronic granulomatous disease, a group of disorders in which phagocytes cannot manufacture O2-, is caused by a biochemical lesion involving this oxidase or its activating system.

MeSH Terms

Cytochrome b Group/analysis,metabolism,physiology Enzyme Activation Granulomatous Disease, Chronic/enzymology,genetics,metabolism Humans NADH, NADPH Oxidoreductases/analysis,metabolism,physiology NADP/metabolism NADPH Oxidases Oxidation-Reduction Oxygen Consumption Phagocytes/enzymology,metabolism Superoxides/metabolism

Chemicals

Cytochrome b Group Superoxides NADP cytochrome b558 NADH, NADPH Oxidoreductases NADPH Oxidases superoxide-forming enzyme

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Babior B M

Division of Biochemistry, Research Institute of Scripps Clinic, La Jolla, California.

Article Info

Journal

Hematology/oncology clinics of North America

Abbr.

Hematol Oncol Clin North Am

ISSN

0889-8588

Published

1988-06-00

Pages

201-12

Language

English

Region

United States

NLM ID

8709473

Subset

Grants

NIAID NIH HHS · AI-24227 · United States

External Links

PubMed source View journal details

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The respiratory burst oxidase.

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