Home LiteratureArticle Details
PMID: 2836629 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Establishment of cytotoxic T-cell clones specific for cells infected with mouse hepatitis virus.

Journal of virology ·Vol. 62 ·No. 7 ·1988-07-00 ·Pages 2505-7

Yamaguchi K, Kyuwa S, Nakanaga K, Hayami M

Abstract

Mouse hepatitis virus (MHV)-specific T-lymphocyte clones were established from MHV-infected BALB/c mice. They expressed Thy1 and Lyt2 antigens but lacked L3T4 and NK1 antigens. The clones killed MHV-infected but not uninfected or influenza virus-infected J774.1 cells. The specificity was further defined by a cold-target competition test.

MeSH Terms
Animals Antigens, Differentiation, T-Lymphocyte/analysis Clone Cells/immunology Cytotoxicity Tests, Immunologic Mice Mice, Inbred BALB C/immunology Murine hepatitis virus/immunology T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antigens, Differentiation, T-Lymphocyte
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yamaguchi K
Department of Animal Pathology, University of Tokyo, Japan.
Kyuwa S
Nakanaga K
Hayami M
References (18)
18 references, click to expand
  1. Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum.
    J Immunol. 1981 May;126(5):1985-9 PMID: 7217676
  2. Immune mediated clearance of JHM virus from the central nervous system.
    Adv Exp Med Biol. 1987;218:399-410 PMID: 2829552
  3. Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed-type hypersensitivity reactions.
    J Exp Med. 1981 Aug 1;154(2):225-34 PMID: 6267157
  4. Induction, control and consequences of virus specific cytotoxic T cells.
    Immunol Rev. 1981;58:157-80 PMID: 6796496
  5. An analysis of effector T cell generation and function in mice exposed to influenza A or Sendai viruses.
    Immunol Rev. 1981;58:5-24 PMID: 6273293
  6. Macrophage antiviral activity: extrinsic versus intrinsic activity.
    Infect Immun. 1982 May;36(2):672-7 PMID: 6282756
  7. Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of cloned virus-specific and H-2-restricted cytotoxic T lymphocytes.
    J Gen Virol. 1983 Feb;64 (Pt 2):443-7 PMID: 6601180
  8. Regulation of interleukin 2 receptor expression on murine cytotoxic T lymphocyte clones.
    J Immunol. 1984 Feb;132(2):839-44 PMID: 6418812
  9. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants.
    J Immunol. 1984 Jul;133(1):433-9 PMID: 6202788
  10. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo.
    J Virol. 1984 Sep;51(3):682-6 PMID: 6332201
  11. Activation of virus specific CTL clones: antigen-dependent regulation of interleukin 2 receptor expression.
    J Immunol. 1985 Feb;134(2):920-5 PMID: 3917480
  12. Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus.
    J Virol. 1986 Jan;57(1):408-12 PMID: 3001363
  13. Natural cytotoxicity against mouse hepatitis virus-infected target cells. I. Correlation of cytotoxicity with virus binding to leukocytes.
    J Immunol. 1986 Feb 15;136(4):1446-53 PMID: 3003198
  14. Natural cytotoxicity against mouse hepatitis virus-infected cells. II. A cytotoxic effector cell with a B lymphocyte phenotype.
    J Immunol. 1986 Feb 15;136(4):1454-60 PMID: 3003199
  15. Cooperation between cytotoxic and helper T lymphocytes in protection against lethal Sendai virus infection. Protection by T cells is MHC-restricted and MHC-regulated; a model for MHC-disease associations.
    J Exp Med. 1986 Sep 1;164(3):723-38 PMID: 3018121
  16. Accumulation and chemotaxis of natural killer/large granular lymphocytes at sites of virus replication.
    J Immunol. 1987 Feb 1;138(3):877-83 PMID: 3027167
  17. Characterization of mouse hepatitis virus-reactive T cell clones.
    Adv Exp Med Biol. 1987;218:391-8 PMID: 2829551
  18. Heterogeneity and specificity of cloned lines of influenza-virus specific cytotoxic T lymphocytes.
    J Exp Med. 1981 Apr 1;153(4):910-23 PMID: 6166708
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.7.2505-2507.1988
Published
1988-07-00
Pages
2505-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253411
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.62.7.2505-2507.1988 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2